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Project B05

Principal Investigator: Prof. Dr. Dirk Hoffmeister

Role of Basidiomycete Small Molecules on Habitat-sharing Microbes

 

Basidiomycetes support ecosystems as symbionts and by maintaining global carbon cycling through lignocellulose breakdown. Bacterial communities are associated with and impact these fungi. Natural products are known to play an interactive role between basidiomycetes and bacteria. For the saprotrophic model brown rot basidiomycete Serpula lacrymans, we found that biofilm- and motility-inhibiting pulvinic acids were biosynthesized when bacteria of various phyla, were present. The regulation of basidiomycete natural product genes in response to the presence of bacterial consortia is entirely unknown.

Schematic summary of basidiomycete responses in dual or multi-partner cultures. An unknown peptidic compound is assumed to serve as cue. The fungal natural products are atromentin-derived pigments. Preliminary evidence shows that in multi-partner culture a second bacterium can override inhibitory properties of another species.

 

This project focuses on S. lacrymans and its metabolites, among them the pulvinic acid family of natural products, to understand the mechanisms and principles how small molecule-based responses to multi-organism environments is induced in the fungus.

 

Team B05

Prof. Dr. Dirk Hoffmeister


Pharmaceutical Microbiology, Institute of Pharmacy

Friedrich Schiller University Jena

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Sebastian Herkersdorf

 


Institute of Pharmacy

Friedrich Schiller University Jena

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